Constriction Restriction

    Table of contents

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    Introduction

    • Important to distinguish b/c treatment is different
      • Constrictive pericarditis is curable
      • Restrictive cardiomyopathy has limited therapeutic options
    • Restrictive Cardiomyopathy (RCM)
      • Myocardial problem that causes impaired relaxation
      • Causes rise in filling pressures and HF
    • Constrictive Pericarditis (CP)
      • Fibrosis and reduced compliance of the pericardial sac

    Causes

    • Causes of constrictive pericarditis (CP):
      • TB ** most common across the world
      • HIV**
      • Connective Tissue Disease
      • Uremia
      • Malignancy
      • Iatrogenic
    • Causes of Restrictive Cardiomyopathy (RCM)
      • Idiopathic
      • Familial (Desmin, Troponin I mutations)
      • Secondary:
        • Radiation
        • Amyloidosis
        • Post-Operative
        • Non-eosinophilic endomyocardial disease (tropical countries)
        • Eosinophilic endomyocardial disease
        • Fabry's
        • Hemochromatosis
        • Sarcoid
        • Scleroderma
        • Carcinoid
        • Medication Induced (Serotonin, ergotamines, anthracycline)
    • Mixed
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