View page
Talk page
Page Notifications Off
  1. Approach To Medicine
  2. Hematology
  3. Heavy Metal Toxicity

Heavy Metal Toxicity

Modified 15:30, 18 Jun 2015 by apavel | Page History
    Table of contents
    1. 1. Lead
    2. 2. Iron
    Table of Contents
    1. 1. Lead
    2. 2. Iron

    .

     

     

    Lead

    • Usually industrial exposure, such as battery manufacturing plant.
    • Symptoms:
      • Hypertension
      • Gout
      • Chronic Kidney Disease (Chronic lead exposure in industry), often one of:
        • Chronic tubulointerstitial nephritis causing proteinuria (with rare leukocytes and erythrocytes in urine sediment).
        • Fanconi syndrome (glycosuria, normoglycemia, hyperuricemia, hypophosphotemia, aminoaciduria). 
    • Testing:
      • Chelation mobilization testing.
        • For long-term lead load and for previous lead exposure. (important in CKD etc..)
        • 90% of total lead in bones (blood levels not adequate indicator)
        • Technique: give chelating agent EDTA --> mobilizes lead deposited in tissues --> measure urine.
      • Erythrocyte protoporphyrin levels
        • For acute exposure. (useless for past exposure)
      • Xrays of long bones
        • In pediatrics (metaphysis of growing bones lights up)
      • Blood smear
        • Basophilic stripping of erythrocytes (also seen in megaloblastic anemia)

     

    Tag page (Edit tags)
    • No tags
    Page statistics
    4418 view(s), 2 edit(s) and 1631 character(s)

    Comments

    You must login to post a comment.

    Attach file

    Attachments