Table of contents
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Rheumatology Serological Markers
Rheumatoid Factor
- Antibody against an Fc portion of Ig (antibody against antibody)
- Seen in RA (70%), Cryoglobulinemia (rheumatoid factors are cryoglobulins)
- Seen 10% of population
DISH
- Diffuse idiopathic skeletal hyperostosis (DISH)
- Defined by the presence of flowing osteophytes involving the anterolateral aspect of the thoracic spine at ≥4 contiguous vertebrae with preservation of the intervertebral disk space (+ absence of apophyseal joint or sacroiliac inflammatory changes such as erosions.)
- DISH may occur with osteoarthritis or inflammatory arthritis (or without) and represents a separate finding of calcification and ossification of spinal ligaments and the regions where tendons and ligaments attach to bone (entheses).
- Unknown cause that is common in the elderly population.
- Symptoms range from asymptomatic or may describe stiffness and reduced range of motion, mostly at the thoracic spine.
Pulmonary Renal Syndrome
- Young pt presents with hemoptysis, elevated creatinine. On urinalysis has blood 3+ and proteins 2+. Urine sediment 50-80 RBC/hpf. 2 RBC casts.
- Pulmonary Renal Syndrome
- Differential diagnosis:
- Goodpastures
- IgA nephropathy
- ANCA-Related (MOST COMMON). 5 Types of ANCA positive syndromes:
- 1. Granulomatosis with polyangiitis (GPA)
- Differential diagnosis:
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